Effects of the Ultimate Detox System are typically felt within 24 to 48 hours, sometimes sooner. Please be aware that as your body acclimates to the protocols of an Ultimate Detox System cycle you may experience fatigue, headaches, sluggishness, and/or mild flu-like symptoms. If symptoms persist longer than 14 days it is advised to lower the detox level and/or dosing. If symptoms worsen it is best to consult your physician.