The ingredients in FOCUS and Calm are natural ingredients and are effective for a year or longer. However, during that time, the appearance of the product might change - CBD tends to change color after a while and we do recommend to optimize the nano-sonification to use the product within 6 months. Refrigerating the product may extend the shelf life beyond 6 months. "shelf life" means unopened product. Upon opening, we recommend using within 60 days.